WASHINGTON (AP) — House Speaker Nancy Pelosi, trying to seize the agenda on a top consumer issue, announced an ambitious prescription drug plan Thursday that would allow Medicare to negotiate prices for seniors and younger people.

The proposal would direct Medicare to bargain over as many as 250, but no fewer than 25, of the costliest drugs. Insulin is on the list. Drugmakers that refuse to negotiate could face steep penalties. Companies that raise prices beyond inflation would have to pay rebates to Medicare.

The plan would limit copays for seniors covered by Medicare’s “Part D” prescription drug program to $2,000. Medicare-negotiated prices would be available to other buyers, such as employer health plans.

It’s shaping up as a high-stakes gamble for all sides in Washington. Polls show that high drug prices have Americans worried, and regardless of party affiliation, they want Congress to act. As a candidate, President Donald Trump called for Medicare negotiations but later seemed to drop the idea.

Pelosi, D-Calif., said her goal is a deal that Trump can sign onto and that could pass the GOP-controlled Senate.

“We don’t want a political issue at the polls,” Pelosi said at a news conference. “We want a solution in Congress, and we want it now.”

Weighing in on Twitter, Trump said, “Let’s get it done in a bipartisan way!” Unlike other Republicans, he refrained from criticizing Pelosi’s bill and said “it’s great” to see her out with a plan. But he said he preferred a bipartisan Senate bill being pushed by Iowa Republican Chuck Grassley.

In the Senate, Republican John Cornyn of Texas said Pelosi’s proposal “has absolutely no chance –zero, zip, nada” of passing. Some House Republicans quickly dismissed it as “socialism.”

The 2003 law that created Medicare’s prescription drug benefit barred the program from negotiating prices, a restriction Democrats have long opposed. Most Republicans say they believe price negotiations are best left to private players such as insurance companies.

The industry group Pharmaceutical Research and Manufacturers of America said Pelosi’s plan was “radical” and would usher in an era of government price-setting that would “blow up” the current system, stifling innovation. But health insurers called the plan “bold reform” and hospitals said it takes “significant strides toward reducing out-of-control drug prices.” Public Citizen, a consumer group on the political left, said the bill didn’t go far enough because it left intact drugmakers’ monopoly on new medicines.

A leading House progressive, Texas Democrat Lloyd Doggett, agreed that more is required. “This new bill was promoted as a way to sway President Trump and a reluctant Republican Senate,” said Doggett. “I await their embrace.”

While the legislation leans left politically it also incorporates ideas from the Trump administration and from Republican and Democratic senators — a signal Pelosi wants a deal.